Britain: ‘Cuts’ both ways

Gene Silencing CUTs Both Ways

There is extensive transcription throughout the eukaryotic genome resulting in both antisense transcripts from coding regions and cryptic unstable transcripts (CUTs) from intergenic regions. In this issue, Camblong et al. (2007) demonstrate in the budding yeast that antisense transcripts, if stabilized by exosome impairment, are able to mediate gene silencing via the recruitment of histone deac...

IKK cuts both ways in Huntington's disease

Opposing motors take the strain M olecular motors show an odd sense of teamwork during cargo transport, say Ally et al. In order to get somewhere, they have to pull in opposite directions. Many types of cargo move through the cell along micro-tubules, but rather than smoothly gliding to their fi nal destinations, they stutter back and forth due to motor proteins that pull in opposite directions...

C. elegans Aging: Proteolysis Cuts Both Ways

Recent reports from two laboratories working on the nematode Caenorhabditis elegans have identified both positive and negative roles for ubiquitin-mediated proteolysis in the regulation of longevity by the insulin/insulin-like growth factor signaling pathway.

Britain cuts back deeply on spending

In the afternoon of October 9, visitors to the Cabinet War Rooms in London experienced a sight more commonly associated with French cities: up to 2,000 scientists, many wearing lab coats or other paraphernalia of their trade, clogged the narrow street between the Treasury and the Foreign Office in London’s government quarters, Whitehall. Carrying placards with slogans like: “Fair funding: it’s ...

Barcan Both Ways